by Evelyn Reinson
On July 3, 2026, the White House’s Office of Information and Regulatory Affairs (OIRA) released its 2026 Unified Regulatory Agenda, outlining anticipated federal regulatory actions and projected timelines. While these timelines remain subject to change, one proposal is drawing significant attention across the food and dietary supplement industry.
The agenda includes a proposed FDA rule to amend 21 CFR Parts 170 and 570, which would require the submission of a Generally Recognized as Safe (GRAS) notice for human and animal food substances that are purported to be GRAS under their intended conditions of use (Regulatory Identifier Number 0910-AJ02).
According to the proposal, FDA would:
Require mandatory GRAS notifications for applicable substances.
Maintain and update a public inventory of submitted GRAS notices.
Clarify the process by which the agency determines that a substance’s use is not GRAS.
Target December 2026 for publication of the proposed rule.
If finalized, these changes could significantly impact the way companies evaluate and document the safety of ingredients intended for use in food.
For more than 90 years, the Natural Products Association has worked to ensure that regulatory policy is grounded in sound science while supporting innovation and consumer access to safe, high-quality natural products. NPA is actively reviewing this proposal and evaluating its potential impact on the industry.
As the rulemaking process moves forward, NPA will continue engaging with members, regulators, and other stakeholders to help ensure the industry’s perspective is represented.
Evelyn Reinson is VP of Brand Marketing and Growth with the Natural Products Association, where she leads the association’s efforts in brand marketing, membership growth, member engagement, digital marketing, sponsorship development, events marketing and strategic growth initiatives.
